Vitamin D signalling in adipose tissue

Ding, Cherlyn and Gao, Dan and Wilding, John and Trayhurn, Paul and Bing, Chen (2012) Vitamin D signalling in adipose tissue. British Journal of Nutrition, 108 (11). pp. 1915-1923. ISSN 0007-1145

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Abstract

Vitamin D deficiency and the rapid increase in the prevalence of obesity are both considered important public health issues. The classical role of vitamin D is in Ca homoeostasis and bone metabolism. Growing evidence suggests that the vitamin D system has a range of physiological functions, with vitamin D deficiency contributing to the pathogenesis of several major diseases, including obesity and the metabolic syndrome. Clinical studies have shown that obese individuals tend to have a low vitamin D status, which may link to the dysregulation of white adipose tissue. Recent studies suggest that adipose tissue may be a direct target of vitamin D. The expression of both the vitamin D receptor and 25-hydroxyvitamin D 1a-hydroxylase (CYP27B1) genes has been shown in murine and human adipocytes. There is evidence that vitamin D affects body fat mass by inhibiting adipogenic transcription factors and lipid accumulation during adipocyte differentiation. Some recent studies demonstrate that vitamin D metabolites also influence adipokine production and the inflammatory response in adipose tissue. Therefore, vitamin D deficiency may compromise the normal metabolic functioning of adipose tissue. Given the importance of the tissue in energy balance, lipid metabolism and inflammation in obesity, understanding the mechanisms of vitamin D action in adipocytes may have a significant impact on the maintenance of metabolic health. In the present review, we focus on the signalling role of vitamin D in adipocytes, particularly the potential mechanisms through which vitamin D may influence adipose tissue development and function.

Item Type:	Article
Uncontrolled Keywords:	Vitamin D; Adipose tissue; Adipocytes; Inflammation; Obesity
Subjects:	Q Science > QP Physiology R Medicine > RZ Other systems of medicine
Divisions:	School of Science > Metabolic Research
Depositing User:	Paul Trayhurn
Date Deposited:	14 Apr 2016 10:52
Last Modified:	14 Apr 2016 10:52
URI:	http://bear.buckingham.ac.uk/id/eprint/21

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