Ding, Cherlyn and Gao, Dan and Wilding, John and Trayhurn, Paul and Bing, Chen (2012) Vitamin D signalling in adipose tissue. British Journal of Nutrition, 108 (11). pp. 1915-1923. ISSN 0007-1145
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Abstract
Vitamin D deficiency and the rapid increase in the prevalence of obesity are both considered important public health issues. The classical role of vitamin D is in Ca homoeostasis and bone metabolism. Growing evidence suggests that the vitamin D system has a range of physiological
functions, with vitamin D deficiency contributing to the pathogenesis of several major diseases, including obesity and the metabolic syndrome. Clinical studies have shown that obese individuals tend to have a low vitamin D status, which may link to the dysregulation of white adipose tissue. Recent studies suggest that adipose tissue may be a direct target of vitamin D. The expression of both the vitamin D receptor and 25-hydroxyvitamin D 1a-hydroxylase (CYP27B1) genes has been shown in murine and human adipocytes.
There is evidence that vitamin D affects body fat mass by inhibiting adipogenic transcription factors and lipid accumulation during adipocyte differentiation. Some recent studies demonstrate that vitamin D metabolites also influence adipokine production and the inflammatory response in adipose tissue. Therefore, vitamin D deficiency may compromise the normal metabolic functioning of adipose tissue. Given the importance of the tissue in energy balance, lipid metabolism and inflammation in obesity, understanding the mechanisms of vitamin D action in adipocytes may have a significant impact on the maintenance of metabolic health. In the present review, we focus
on the signalling role of vitamin D in adipocytes, particularly the potential mechanisms through which vitamin D may influence adipose tissue development and function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Vitamin D; Adipose tissue; Adipocytes; Inflammation; Obesity |
| Subjects: | Q Science > QP Physiology R Medicine > RZ Other systems of medicine |
| Divisions: | School of Science > Metabolic Research |
| Depositing User: | Paul Trayhurn |
| Date Deposited: | 14 Apr 2016 10:52 |
| Last Modified: | 14 Apr 2016 10:52 |
| URI: | https://bear.buckingham.ac.uk/id/eprint/21 |
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