Recruiting brown adipose tissue in human obesity

Trayhurn, Paul (2016) Recruiting brown adipose tissue in human obesity. Diabetes, 65.


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Obesity remains a major biomedical challenge with the associated diseases, particularly insulin resistance and type 2 diabetes, imposing a substantial and increasing burden on healthcare systems. In the US, one-third of adults are classed as obese (BMI >30), while in the UK, which has one of the highest incidence rates in Europe, 25% are obese. Conceptually, the treatment of obesity is simple: energy expenditure must exceed energy intake. In the late 1970’s it was proposed, primarily from studies on rats and mice, that reduced expenditure on adaptive heat production (thermogenesis) associated with a specialised fat tissue – brown adipose tissue (BAT) – is central to the development of obesity. Correspondingly, for a period stimulation of heat production in BAT was seen as a potential therapeutic route for reversing obesity and there was a search for agents that would stimulate the activity of the tissue.

Item Type: Article
Additional Information: Final accepted version deposited
Uncontrolled Keywords: Commentary
Subjects: Q Science > QP Physiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: School of Science > Metabolic Research
Depositing User: Paul Trayhurn
Date Deposited: 15 Apr 2016 13:18
Last Modified: 15 Feb 2018 13:36

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